Abstract

The gastrointestinal (GI) tract of mammals is inhabited by trillions of microorganisms, resulting in exceedingly complex networking. The interaction between distinct bacterial species and the host immune system is essential in maintaining homeostasis in the gut ecosystem. For instance, the gut commensal microbiota dictates intestinal mucosa maturation and its abundant immune components, such as cytoprotective heat shock proteins (HSP). Here we examined physiological expression of HSP in the normal porcine GI tract and found it to be gut region-and cell type-specific in response to dietary components, microbes, and microbial metabolites to which the mucosa surface is exposed. Correlations between HSP72 expression and ileal Lactobacillus spp. and colonic clostridia species, and between HSP27 expression and uronic acid ingestion, were important interplays identified here. Thus this study provides novel insights into host-microbe interactions shaping the immune system that are modifiable by dietary regime.

Keywords

heat shock proteins 27 and 72; porcine gut microbiota; mucosal immune system; dietary fiber

Published in

AJP - Gastrointestinal and Liver Physiology
2014, Volume: 306, number: 12, pages: G1033-G1041
Publisher: AMER PHYSIOLOGICAL SOC

SLU Authors

• Liu, Haoyu

  • Department of Applied Animal Science and Welfare, Swedish University of Agricultural Sciences
    

• Dicksved, Johan

  • Department of Applied Animal Science and Welfare, Swedish University of Agricultural Sciences
    

• Lundh, Torbjörn

  • Department of Applied Animal Science and Welfare, Swedish University of Agricultural Sciences
    

• Lindberg, Jan Erik

  • Department of Applied Animal Science and Welfare, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Biochemistry and Molecular Biology
Cell Biology


Publication identifier

DOI: https://doi.org/10.1152/ajpgi.00299.2013

Permanent link to this page (URI)

https://res.slu.se/id/publ/61020