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Forskningsartikel2005Vetenskapligt granskad

Relationship between the activities of cytochromes P4502E1 and P4502A6 and skatole content in fat in entire male pigs fed with and without raw potato starch

Zamaratskaia, Galia; Squires, Jim; Babol, Jakub; Andersson, Kristina; Andersson, Kjell; Lundström, Kerstin


The objective of this study was to evaluate the potential impact of the dietary supplement of raw potato starch (RPS) on the relationship between skatole in fat and the activities of cytochromes P4502E1 (CYP2E1) and P4502A6 (CYP2A6) in entire male pigs. A total of 111 entire male pigs of a crossbred (Yorkshire dams×Swedish Landrace sires) were used in this study. Animals were divided into three groups. Group 1 consisted of 35 entire males slaughtered at 90 kg live weight (LW) and fed commercial diet; group 2, 43 entire males slaughtered at 115 kg LW and fed commercial diet; and group 3, 33 entire males slaughtered at 115 kg LW and fed commercial diet with addition of RPS (Lyckeby Culminar AB), 0.6 kg per pig per day, the last 2 weeks prior to slaughter. Fat and liver samples were taken at slaughter. Fat samples were analysed for skatole content, and liver samples for the activities of CYP2E1 and CYP2A6. The levels of skatole in fat were significantly lower in groups of low-weight entire males and the activities of hepatic CYP2E1 and CYP2A6 were higher in low-weight males (P<0.001). Enzyme activities did not differ between groups slaughtered at 115 kg and fed diets with and without addition of RPS. The age-related increase in skatole levels might be due to the decreased activities of cytochromes CYP2E1 and CYP2A6. Addition of RPS to the diet significantly reduced the levels of skatole in fat. Cytochromes CYP2E1 and CYP2A6 are not involved in the mechanism of this reduction


Entire male pigs; Skatole; Raw potato starch; Cytochrome P4502E1; Cytochrome P4502A6

Publicerad i

Livestock Production Science
2005, Volym: 95, sidor: 83-88