Effects of pharmaceuticals present in aquatic environment on Phase I metabolism in fish

Abstract

The fate of pharmaceuticals in aquatic environments is an issue of concern. Current evidence indicates that the risks to fish greatly depend on the nature and concentrations of the pharmaceuticals and might be species-specific. Assessment of risks associated with the presence of pharmaceuticals in water is hindered by an incomplete understanding of the metabolism of these pharmaceuticals in aquatic species. In mammals and fish, pharmaceuticals are primarily metabolized by cytochrome P450 enzymes (CYP450). Thus, CYP450 activity is a crucial factor determining the detoxification abilities of organisms. Massive numbers of toxicological studies have investigated the interactions of human pharmaceuticals with detoxification systems in various fish species. In this paper, we review the effects of pharmaceuticals found in aquatic environments on fish hepatic CYP450. Moreover, we discuss the roles of nuclear receptors in cellular regulation and the effects of various groups of chemicals on fish, presented in the recent literature.

Keywords

Aquatic invertebrates; Cytochromes P450; Nuclear receptor; Drugs

Published in

Environmental toxicology and pharmacology
2015, volume: 40, number: 2, pages: 430–444

SLU Authors

• Burkina, Viktoriia

  • University of South Bohemia in České Budějovice

• Zlabek, Vladimir

  • University of South Bohemia in České Budějovice

• Zamaratskaia, Galia

  • Department of Molecular Sciences, Swedish University of Agricultural Sciences
    
  • University of South Bohemia in České Budějovice

Global goals (SDG)

SDG3 Good health and well-being
SDG6 Clean water and sanitation

UKÄ Subject classification

Molecular Biology
Biochemistry

Publication identifier

• DOI: https://doi.org/10.1016/j.etap.2015.07.016

Permanent link to this page (URI)

https://res.slu.se/id/publ/68272