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Research article2015Peer reviewedOpen access

Dynamic expression of leukocyte innate immune genes in whole blood from horses with lipopolysaccharide-induced acute systemic inflammation

Vinther, AML; Skovgaard, K; Heegaard, PMH; Andersen, PH

Abstract

Conclusions: This first broad study of gene expressions in blood leukocytes during equine acute LPS-induced systemic inflammation thoroughly characterized a highly regulated and dynamic innate immune response. These results provide new insights into the molecular mechanisms of equine systemic inflammation.

Keywords

Baseline expression variability; Cytokines; Endotoxemia; Equine; Gene expression dynamics; Innate immunity; Leukocytes; Lipopolysaccharide; Systemic inflammation; Time course study

Published in

BMC Veterinary Research
2015, Volume: 11, article number: 134

    UKÄ Subject classification

    Other Veterinary Science

    Publication identifier

    DOI: https://doi.org/10.1186/s12917-015-0450-5

    Permanent link to this page (URI)

    https://res.slu.se/id/publ/68760