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Research article - Peer-reviewed, 2015

Dynamic expression of leukocyte innate immune genes in whole blood from horses with lipopolysaccharide-induced acute systemic inflammation

Vinther, AML; Skovgaard, K; Heegaard, PMH; Andersen, PH

Abstract

Conclusions: This first broad study of gene expressions in blood leukocytes during equine acute LPS-induced systemic inflammation thoroughly characterized a highly regulated and dynamic innate immune response. These results provide new insights into the molecular mechanisms of equine systemic inflammation.

Keywords

Baseline expression variability; Cytokines; Endotoxemia; Equine; Gene expression dynamics; Innate immunity; Leukocytes; Lipopolysaccharide; Systemic inflammation; Time course study

Published in

BMC Veterinary Research
2015, volume: 11, article number: 134

Authors' information

Vinther, Anne Mette L.
University of Copenhagen
Skovgaard, Kerstin
Technical University of Denmark (DTU)
Heegaard, Peter M. H.
Technical University of Denmark (DTU)
Andersen, Pia Haubro (Haubro Andersen, Pia)
Swedish University of Agricultural Sciences, Department of Clinical Sciences

UKÄ Subject classification

Other Veterinary Science

Publication Identifiers

DOI: https://doi.org/10.1186/s12917-015-0450-5

URI (permanent link to this page)

https://res.slu.se/id/publ/68760