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A KCNJ10 mutation previously identified in the Russell group of terriers also occurs in Smooth-Haired Fox Terriers with hereditary ataxia and in related breeds

Rohdin C, Gilliam D, O'Leary CA, O'Brien DP, Coates JR, Johnson GS, Jäderlund KH

Sammanfattning

Conclusions: A KCNJ10 mutation, previously associated with an autosomal recessive spinocerebellar ataxia in Jack Russell Terriers, Parson Russell Terriers, and Russell Terriers segregates in at least three more breeds descended from British hunting terriers. Ataxic members of two of these breeds, the Smooth-Haired Fox Terrier and the Toy Fox Terrier, were homozygous for the mutation, strengthening the likelihood that this genetic defect is indeed the causative mutation for the disease known as "hereditary ataxia" in Fox Terriers and "spinocerebellar ataxia with myokymia, seizures or both" in the Russell group of terriers.

Nyckelord

Dog; Spinocerebellar ataxia; Myokymia; Smooth-Haired Fox Terrier; Toy Fox Terrier; Jack Russell Terrier; Parson Russell Terrier; Russell Terrier; Tenterfield Terrier; KCNJ10

Publicerad i

Acta Veterinaria Scandinavica
2015, Volym: 57, nummer: 26

    UKÄ forskningsämne

    Annan veterinärmedicin

    Publikationens identifierare

    DOI: https://doi.org/10.1186/s13028-015-0115-1

    Permanent länk till denna sida (URI)

    https://res.slu.se/id/publ/70522