Johnzon, Carl-Fredrik
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
Sammanfattning
Mast cells (MCs) are particularly abundant at host-environment interfaces, such as skin and intestinal mucosa. Because of their Location, it has been hypothesized that MCs can act as sentinel cells that sense microbial attacks and initiate a protective immune response. Several studies have suggested that animals deficient in MCs exhibit a worsened pathology in various experimental models of bacterial infection. However, other studies have indicated that MCs under certain circumstances may have a detrimental impact on bacterial disease, and there are also recent studies indicating that MCs are dispensable for the clearance of bacterial pathogens. Herein, we review the current knowledge of the role of MCs in bacterial infection.
Nyckelord
mast cells
Publicerad i
American Journal of Pathology
2016, volym: 186, nummer: 1, sidor: 4-14
Utgivare: ELSEVIER SCIENCE INC
SLU författare
Rönnberg, Elin
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
Pejler, Gunnar
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
- Uppsala universitet
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
Associerade SLU-program
Framtidens djurhälsa och djurvälfärd (tom Jan 2017)
UKÄ forskningsämne
Immunologi inom det medicinska området
Publikationens identifierare
- DOI: https://doi.org/10.1016/j.ajpath.2015.06.024
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/79428