Thyroid receptor ligands. 6. A high affinity

Koehler, Konrad; Gordon, Sandra; Brandt, Peter; Carlsson, Bo; Backsbro-Saeidi, Anna; Apelqvist, Theresa; Agback, Peter; Grover, Gary J.; Nelson, William; Grynfarb, Marlena; Farnegardh, Mathias; Rehnmark, Stefan; Malm, Johan

doi:10.1021/jm060521i

Research article2006Peer reviewed

Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor

Koehler, Konrad; Gordon, Sandra; Brandt, Peter; Carlsson, Bo; Backsbro-Saeidi, Anna; Apelqvist, Theresa; Agback, Peter; Grover, Gary J.; Nelson, William; Grynfarb, Marlena; Farnegardh, Mathias; Rehnmark, Stefan; Malm, Johan

Abstract

A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.

Published in

Journal of Medicinal Chemistry
2006, volume: 49, number: 23, pages: 6635-6637
Publisher: AMER CHEMICAL SOC

SLU Authors

Agback, Peter
- Karo Bio AB

UKÄ Subject classification

Organic Chemistry

Publication identifier

DOI: https://doi.org/10.1021/jm060521i

Permanent link to this page (URI)

https://res.slu.se/id/publ/83871