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Forskningsartikel2015Vetenskapligt granskadÖppen tillgång

Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts

Hampel, Regina; Peters, Annette; Beelen, Rob; Brunekreef, Bert; Cyrys, Josef; de Faire, Ulf; de Hoogh, Kees; Fuks, Kateryna; Hoffmann, Barbara; Huels, Anke; Imboden, Medea; Jedynska, Aleksandra; Kooter, Ingeborg; Koenig, Wolfgang; Kuenzli, Nino; Leander, Karin; Magnusson, Patrik; Mannisto, Satu; Penell, Johanna; Pershagen, Goran;
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Background: Epidemiological studies have associated long-term exposure to ambient particulate matter with increased mortality from cardiovascular and respiratory disorders. Systemic inflammation is a plausible biological mechanism behind this association. However, it is unclear how the chemical composition of PM affects inflammatory responses.Objectives: To investigate the association between long-term exposure to elemental components of PM and the inflammatory blood markers high-sensitivity C-reactive protein (hsCRP) and fibrinogen as part of the European ESCAPE and TRANSPHORM multi-center projects. Methods: In total, 21,558 hsCRP measurements and 17,428 fibrinogen measurements from cross-sections of five and four cohort studies were available, respectively. Residential long-term concentrations of particulate matter <10 mu m (PM10) and <2.5 mu m (PM2.5) in diameter and selected elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, zinc) were estimated based on land-use regression models. Associations between components and inflammatory markers were estimated using linear regression models for each cohort separately. Cohort-specific results were combined using random effects meta-analysis. As a sensitivity analysis the models were additionally adjusted for PM mass.Results: A 5 ng/m(3) increase in PM2.5 copper and a 500 ng/m(3) increase in PM10 iron were associated with a 6.3% [0.7; 12.3%] and 3.6% [0.3; 7.1%] increase in hsCRP, respectively. These associations between components and fibrinogen were slightly weaker. A 10 ng/m(3) increase in PM2.5 zinc was associated with a 1.2% [0.1; 2.4%] increase in fibrinogen; confidence intervals widened when additionally adjusting for PM2.5.Conclusions: Long-term exposure to transition metals within ambient particulate matter, originating from traffic and industry, may be related to chronic systemic inflammation providing a link to long-term health effects of particulate matter. (C) 2015 Elsevier Ltd. All rights reserved.


Long-term exposure; Particulate matter; Elemental components; Inflammation; ESCAPE; TRANSPHORM

Publicerad i

Environment International
2015, Volym: 82, sidor: 76-84

    UKÄ forskningsämne

    Miljömedicin och yrkesmedicin
    Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

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