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Forskningsartikel2016Vetenskapligt granskadÖppen tillgång

Particulate matter air pollution components and risk for lung cancer

Raaschou-Nielsen, O.; Beelen, R.; Wang, M.; Hoek, G.; Andersen, Z. J.; Hoffmann, B.; Stafoggia, M.; Samoli, E.; Weinmayr, G.; Dimakopoulou, K.; Nieuwenhuijsen, M.; Xun, W. W.; Fischer, P.; Eriksen, K. T.; Sorensen, M.; Tjonneland, A.; Ricceri, F.; De Hoogh, K.; Key, T.; Eeftens, M.;
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Background: Particulate matter (PM) air pollution is a human lung carcinogen; however, the components responsible have not been identified. We assessed the associations between PM components and lung cancer incidence.Methods: We used data from 14 cohort studies in eight European countries. We geocoded baseline addresses and assessed air pollution with land-use regression models for eight elements (Cu, Fe, K, Ni, S, Si, V and Zn) in size fractions of PM2.5 and PM10. We used Cox regression models with adjustment for potential confounders for cohort-specific analyses and random effect models for meta-analysis.Results: The 245,782 cohort members contributed 3,229,220 person-years at risk. During follow-up (mean, 13.1 years), 1878 incident cases of lung cancer were diagnosed. In the meta-analyses, elevated hazard ratios (HRs) for lung cancer were associated with all elements except V; none was statistically significant In analyses restricted to participants who did not change residence during follow-up, statistically significant associations were found for PM2.5 Cu (HR, 125; 95% Cl, 1.01-1.53 per 5 ng/m(3)), PM10 Zn (1.28; 1.02-1.59 per 20 ng/m3), PMio S (1.58; 1.03-2.44 per 200 ng/m(3)), PM10 Ni (1.59; 1.12-2.26 per 2 ng/m(3)) and PM10K (1.17; 1.02-1.33 per 100 ng/m(3)). In two-pollutant models, associations between PMio and PM2.5 and lung cancer were largely explained by PM2.5 S.Conclusions: This study indicates that the association between PM in air pollution and lung cancer can be attributed to various PM components and sources. PM containing S and Ni might be particularly important. (C) 2015 Elsevier Ltd. All rights reserved.


Air pollution; Particulate matter; Sulfur; Nickel; Cohort study; Lung cancer

Publicerad i

Environment International
2016, Volym: 87, sidor: 66-73

    UKÄ forskningsämne

    Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
    Miljömedicin och yrkesmedicin

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