Molecular Diversification in the Quorum-Sensing System of Vibrio cholerae: Role of Natural Selection in the Emergence of Pandemic Strains

Abstract

Two haplotypes of the Vibrio cholerae quorum-sensing system regulator hapR are described: hapR1, common among nonpandemic, non-O1, non-O139 strains, and hapR2, associated with pandemic O1 and O139 and epidemic O37 V. cholerae strains. The hapR2 has evolved under strong natural selection, implying that its fixation was influenced by conditions that led to cholera pandemics.

Published in

Applied and Environmental Microbiology
2009, volume: 75, number: 11, pages: 3808-3812
Publisher: AMER SOC MICROBIOLOGY

SLU Authors

• Ingvarsson, Pär

  • Umeå University

UKÄ Subject classification

Microbiology
Evolutionary Biology

Publication identifier

• DOI: https://doi.org/10.1128/AEM.02496-08

Permanent link to this page (URI)

https://res.slu.se/id/publ/84119