Research article2009Peer reviewedOpen access
Molecular Diversification in the Quorum-Sensing System of Vibrio cholerae: Role of Natural Selection in the Emergence of Pandemic Strains
Talyzina, Nina M.; Ingvarsson, Par K.; Zhu, Jun; Wai, Sun N.; Andersson, Agneta
Abstract
Two haplotypes of the Vibrio cholerae quorum-sensing system regulator hapR are described: hapR1, common among nonpandemic, non-O1, non-O139 strains, and hapR2, associated with pandemic O1 and O139 and epidemic O37 V. cholerae strains. The hapR2 has evolved under strong natural selection, implying that its fixation was influenced by conditions that led to cholera pandemics.
Published in
Applied and Environmental Microbiology
2009, Volume: 75, number: 11, pages: 3808-3812 Publisher: AMER SOC MICROBIOLOGY
UKÄ Subject classification
Microbiology
Evolutionary Biology
Publication identifier
DOI: https://doi.org/10.1128/AEM.02496-08
Permanent link to this page (URI)
https://res.slu.se/id/publ/84119