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Research article2017Peer reviewed

Microcystins activate nuclear factor erythroid 2-related factor 2 (Nrf2) in human liver cells in vitro - Implications for an oxidative stress induction by microcystins

Lundqvist, Johan; Pekar, Heidi; Oskarsson, Agneta

Abstract

Microcystins, a potential threat to drinking water quality, are hepatotoxic but it has remained unclear if microcystins induce oxidative stress. We investigated if four microcystins could activate the Nrf2 pathway, a regulator of oxidative stress response. Nrf2 activity was significantly increased by microcystin-LR and-RR at 10 mu M, by microcystin-LY at 3 mu M, by [D-Asp3]-LR and by microcystin-LR at 1 mu M. Our results lend support to the suggestion that microcystins may induce oxidative stress response. (C) 2016 Elsevier Ltd. All rights reserved.

Keywords

Microcystins; Oxidative stress; Nrf2

Published in

Toxicon
2017, Volume: 126, pages: 47-50

      SLU Authors

      • Sustainable Development Goals

      Ensure availability and sustainable management of water and sanitation for all

      UKÄ Subject classification

      Environmental Health and Occupational Health
      Pharmacology and Toxicology

      Publication identifier

      DOI: https://doi.org/10.1016/j.toxicon.2016.12.012

      Permanent link to this page (URI)

      https://res.slu.se/id/publ/88794