Lundqvist, Johan
- Department of Biomedical Science and Veterinary Public Health, Swedish University of Agricultural Sciences
Research article - Peer-reviewed, 2017
Microcystins activate nuclear factor erythroid 2-related factor 2 (Nrf2) in human liver cells in vitro - Implications for an oxidative stress induction by microcystins
Lundqvist, Johan; Pekar, Heidi; Oskarsson, Agneta
Abstract
Microcystins, a potential threat to drinking water quality, are hepatotoxic but it has remained unclear if microcystins induce oxidative stress. We investigated if four microcystins could activate the Nrf2 pathway, a regulator of oxidative stress response. Nrf2 activity was significantly increased by microcystin-LR and-RR at 10 mu M, by microcystin-LY at 3 mu M, by [D-Asp3]-LR and by microcystin-LR at 1 mu M. Our results lend support to the suggestion that microcystins may induce oxidative stress response. (C) 2016 Elsevier Ltd. All rights reserved.
Keywords
Microcystins; Oxidative stress; Nrf2
Published in
Toxicon
2017, Volume: 126, pages: 47-50
Oskarsson, Agneta
- Department of Biomedical Science and Veterinary Public Health, Swedish University of Agricultural Sciences
- Department of Biomedical Science and Veterinary Public Health, Swedish University of Agricultural Sciences
SLU Authors
Sustainable Development Goals
SDG6 Clean water and sanitation
UKÄ Subject classification
Environmental Health and Occupational Health
Pharmacology and Toxicology
Publication Identifiers
DOI: https://doi.org/10.1016/j.toxicon.2016.12.012
Permanent link to this page (URI)
https://res.slu.se/id/publ/88794