Lundqvist, Johan
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Research article2017Peer reviewed
Lundqvist, Johan; Pekar, Heidi; Oskarsson, Agneta
Microcystins, a potential threat to drinking water quality, are hepatotoxic but it has remained unclear if microcystins induce oxidative stress. We investigated if four microcystins could activate the Nrf2 pathway, a regulator of oxidative stress response. Nrf2 activity was significantly increased by microcystin-LR and-RR at 10 mu M, by microcystin-LY at 3 mu M, by [D-Asp3]-LR and by microcystin-LR at 1 mu M. Our results lend support to the suggestion that microcystins may induce oxidative stress response. (C) 2016 Elsevier Ltd. All rights reserved.
Microcystins; Oxidative stress; Nrf2
Toxicon
2017, Volume: 126, pages: 47-50
SDG6 Clean water and sanitation
Environmental Health and Occupational Health
Pharmacology and Toxicology
DOI: https://doi.org/10.1016/j.toxicon.2016.12.012
https://res.slu.se/id/publ/88794