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Research article - Peer-reviewed, 1997

Effect of diet on milk allantoin and its relationship with urinary allantoin in dairy cows

Gonda, HL; Lindberg, JE


The present study examined the effects of diet on the concentration and excretion of allantoin in milk and the relationship between allantoin in milk and urine of dairy cows. Results are reported from three experiments. In Experiment 1, four diets with two different protein percentages and two different rumen degradabilities were fed to 12 cows in a continuous trial. In Experiment 2, four diets with different protein balance values in the rumen were fed to four cows in a 4 x 4 Latin square design. In Experiment 3, four diets with different contents of concentrate and fat were fed to four cows in two incomplete 2 x 2 Latin squares. The excretion of allantoin N in milk increased as dry matter intake increased (Experiment 1) and as the concentrate in the diet increased (Experiment 3). In Experiments 1 and 3, the excretion of allantoin in milk was correlated with its concentration in milk and with its excretion in urine. In the three experiments, allantoin excretion in milk was closely correlated with milk yield. The amount of allantoin secreted in milk represented a small proportion (0.63 to 1.34%) of the total excretion in urine and milk. The proportion of allantoin secreted in milk was negatively correlated with the urinary excretion of allantoin in Experiments 2 and 3 and positively correlated with the excretion of allantoin in milk in Experiment 1. In Experiments 1 and 2, the proportion of allantoin excreted in milk was not constant but increased as milk yield increased.


purine derivatives; milk allantoin; urinary allantoin; dairy cows

Published in

Journal of Dairy Science
1997, Volume: 80, number: 2, pages: 364-373