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Cellular and humoral immune alterations during the clinical and recovery phases of experimental swine dysentery

Jonasson, Robert; Andersson, Märit; Råsbäck, Therese; Johannisson, Anders; Fellström, Claes; Jensen, Waern Marianne


Pigs were inoculated with B.hyodysenteriae. Blood was sampled before inoculation, at clinical signs of swine dysentery and during 3 weeks of recovery. Dysentery pigs had elevated levels of Serum Amyloid A and circulating neutrophils, monocytes, CD8+ cells and activated (CD45RA) lymphocytes during dysentery. The CD8+ cells where mainly CD4and CD8. There was a decrease in B cells and an increase in  T cells after inoculation. Serum antibodies where present at day 7 of the recovery from clinical symptoms and onwards. The alterations in protein metabolism and its role will also be addressed

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International Conference on Colonic Spirochaetal Infections