Abstract

Environmental perturbations induce transcriptional changes, some of which may be inherited even in the absence of the initial stimulus. Previous studies have focused on transfers through the germline although microbiota is also passed on to the offspring. Thus, we inspected the involvement of the gut microbiome in transgenerational inheritance of environmental exposures in Drosophila melanogaster. We grew flies in the cold versus control temperatures and compared their transcriptional patterns in both conditions as well as in their offspring. F2 flies grew in control temperature, while we controlled their microbiota acquisition from either F1 sets. Transcriptional status of some genes was conserved transgenerationally, and a subset of these genes, mainly expressed in the gut, was transcriptionally dependent on the acquired microbiome.

Keywords

Drosophila melanogaster; environmental response; gut microbiota; host-microbiome interaction

Published in

FEBS Letters
2018, Volume: 592, number: 24, pages: 4078-4086
Publisher: WILEY

SLU Authors

• Delhomme, Nicolas

  • Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Microbiology


Publication identifier

DOI: https://doi.org/10.1002/1873-3468.13278

Permanent link to this page (URI)

https://res.slu.se/id/publ/97654