Asymmetric Synthesis of alpha- and beta-Benzylhydroxy-gamma-butyrolactones

Sammanfattning

Herein we describe a new asymmetric synthesis of alpha-benzyl-alpha-hydroxy-gamma-butyrolactone, a core building block of new HIV-1 protease inhibitors containing a tertiary alcohol in the transition-state mimic. Immediate access to beta-benzyl-beta-hydroxy-gamma-butyrolactone is also possible from a common intermediate. Both lactones are useful building blocks in their own right.

Nyckelord

lactones; asymmetric catalysis; epoxidations; oxidations; HIV

Publicerad i

Synlett
2010, nummer: 1, sidor: 131-133
Utgivare: GEORG THIEME VERLAG KG

UKÄ forskningsämne

Organisk kemi


Publikationens identifierare

DOI: https://doi.org/10.1055/s-0029-1218529

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/99464