Nord, Christina
- The Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences
Research article2014Peer reviewedOpen access
Cytotoxic Illudalane Sesquiterpenes from the Wood-Decay Fungus Granulobasidium vellereum (Ellis & Cragin) Julich
Nord, Christina; Menkis, Audrius; Broberg, Anders
Abstract
Seven illudalane sesquiterpenes were obtained from the wood decomposing fungus Granulobasidium vellereum: granuloinden A, granuloinden B and dihydrogranuloinden, along with the previously known compounds radulactone, pterosin M, echinolactone A and D. Granuloinden B showed potent cytotoxic activity against the Huh7 and MT4 tumor cell lines (CC50 values of 6.7 and 0.15 mu M, respectively), whereas granuloinden A and dihydrogranuloinden had no or moderate activity.
Keywords
Granulobasidium vellereum; sesquiterpenes; illudalane; cytotoxic
Published in
Molecules
2014, volume: 19, number: 9, pages: 14195-14203
Publisher: MDPI AG
SLU Authors
Menkis, Audrius
- Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences
- Department of Forest Mycology and Plant Pathology, Swedish University of Agricultural Sciences
Broberg, Anders
- The Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences
- The Department of Chemistry and Biotechnology, Swedish University of Agricultural Sciences
UKÄ Subject classification
Organic Chemistry
Microbiology
Publication identifier
- DOI: https://doi.org/10.3390/molecules190914195
Permanent link to this page (URI)
https://res.slu.se/id/publ/63281