Ekesten, Björn
- Institutionen för kirurgi och medicin, stordjur, Sveriges lantbruksuniversitet
Sammanfattning
Purpose: Because the mouse lacks a typical Purkinje shift, we have examined its light-adapted ERG to determine whether there was other evidence in addition to tolerance to background light, that could be used to identify cone function in the ERG. Methods: Full field comeal ERGs to white flashes, double flashes and flash trains were examined in the presence of a strong full field light adaptation and compared with the human cone ERG. Results: The following cone-like properties could be identified. (1)The light-adapted murine ERG increases in amplitude gradually during the first 10 minutes of light-adaptation (2) It is capable of responding to a 50 Hz stimulus, although its overall frequency response is slower than that of the human cone ERG; (3) A corneal positive d-wave occurs to the termination of a Bash train; (4) The response increases linearly with light intensity. Conclusion: The light adapted murine ERG has several properties of cones but it has a slower response than the human cone ERG.
Nyckelord
cone function; d-wave; electroretinogram; light-adaptation; mouse
Publicerad i
Documenta Ophthalmologica
1999, volym: 97, nummer: 1, sidor: 23-31
Utgivare: KLUWER ACADEMIC PUBL
SLU författare
UKÄ forskningsämne
Oftalmologi
Publikationens identifierare
- DOI: https://doi.org/10.1023/A:1001869212639
Permanent länk till denna sida (URI)
https://res.slu.se/id/publ/107292