Genetic Variants and Disease-Associated Factors Contribute to Enhanced Interferon Regulatory Factor 5 Expression in Blood Cells of Patients With Systemic Lupus Erythematosus

Feng, D; Stone, Rivka C.; Eloranta, Maija-Leena; Sangster-Guity, N; Nordmark, Gunnel; Sigurdsson, Snaevar; Wang, Chuan; Alm, Gunnar; Syvänen, Ann-Christine; Rönnblom, Lars; Barnes, Betsy J.

doi:10.1002/art.27223

Forskningsartikel2010Vetenskapligt granskadÖppen tillgång

Genetic Variants and Disease-Associated Factors Contribute to Enhanced Interferon Regulatory Factor 5 Expression in Blood Cells of Patients With Systemic Lupus Erythematosus

Feng, D; Stone, Rivka C.; Eloranta, Maija-Leena; Sangster-Guity, N; Nordmark, Gunnel; Sigurdsson, Snaevar; Wang, Chuan; Alm, Gunnar; Syvänen, Ann-Christine; Rönnblom, Lars; Barnes, Betsy J.

Sammanfattning

Conclusion. This study provides the first formal proof that IRF-5 expression and alternative splicing are significantly up- regulated in primary blood cells of patients with SLE. Furthermore, the risk haplotype is associated with enhanced IRF-5 transcript and protein expression in patients with SLE.

Publicerad i

Arthritis and Rheumatism
2010, volym: 62, nummer: 2, sidor: 562-573
Utgivare: WILEY-BLACKWELL

SLU författare

Eloranta, Maija-Leena
- Uppsala universitet
Alm, Gunnar
- Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet

UKÄ forskningsämne

Klinisk medicin

Publikationens identifierare

DOI: https://doi.org/10.1002/art.27223

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/48073