Pseudotrienic acids A and B, two bioactive metabolites from Pseudomonas sp MF381-IODS

Sammanfattning

Bioassay-guided fractionation of the liquid culture broth of Pseudomonas sp. MF381-IODS yielded two new antimicrobial substances, identified as (2E,4E,6E)-9-[((2S,3R)-3-hydroxy-4-{[(3E,5E,7RS)-7-hydroxy-4-methylhexadeca-3,5-dienoyl]amino}-2-methylbutanoyl)amino]nona-2,4,6-trienoic acid and the tetradeca equivalent, named pseudotrienic acids A (1) and B (2), respectively. The compounds are prone to lactone formation, and their structures suggest them to be derived from ring opening of a macrolide. Pseudotrienic acids A and B inhibited growth of Staphylococcus aureus (MIC 70 mu g/mL) and Pseudomonas syringae pv. syringae (MIC 70 mu g/mL). Two known antimicrobial compounds, the polyketide 2,3-deepoxy-2,3-didehydrorhizoxin (3) and the tryptophan-derived pyrrolnitrin (4), were also identified

Publicerad i

Journal of Natural Products
2005, volym: 68, nummer: 9, sidor: 1380-1385
Utgivare: AMER CHEMICAL SOC

SLU författare

• Pohanka, Anton

  • Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
    

• Broberg, Anders

  • Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
    

• Johansson, Maria

  • Institutionen för skoglig mykologi och växtpatologi, Sveriges lantbruksuniversitet
    

• Kenne, Lennart

  • Institutionen för molekylära vetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Jordbruksvetenskap

Publikationens identifierare

• DOI: https://doi.org/10.1021/np050243a

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/7378