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Sammanfattning

Malaria infection renders humans more attractive to Anopheles gambiae sensu lato mosquitoes than uninfected people. The mechanisms remain unknown. Here, we show that an isoprenoid precursor produced by Plasmodium falciparum, (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), affects A. gambiae s.l. blood meal seeking and feeding behaviors, as well as susceptibility to infection. HMBPP acts indirectly by triggering human red blood cells to increase the release of CO2, aldehydes, and monoterpenes, which together enhance vector attraction, and stimulate vector feeding. When offered in a blood meal, HMBPP modulates neural, antimalarial, and oogenic gene transcription without affecting mosquito survival or fecundity, while in a P. falciparum infected blood meal, sporogony is increased.

Publicerad i

Science
2017, volym: 355, nummer: 6329, sidor: 1076 - 1080

SLU författare

Globala målen (SDG)

SDG3 God hälsa och välbefinnande

UKÄ forskningsämne

Ekologi
Etologi

Publikationens identifierare

  • DOI: https://doi.org/10.1126/science.aah4563

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/79954