Lundequist, Anders
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Research article2014Peer reviewedOpen access
Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner
Põlajeva, Jelena; Lundequist, Anders; Pejler, Gunnar; Tchougounova, Elena
Abstract
Further, both glioma-conditioned media and purified MIF promoted differential phosphorylation of a number of signaling molecules, including signal transducer and activator of transcription 5 (STAT5), in MCs. Inhibition of pSTAT5 signaling significantly attenuated the migration of MCs toward glioma cell-conditioned medium shown to contain MIF. In addition, analysis of tissue microarrays (TMAs) of high-grade gliomas revealed a direct correlation between the level of pSTAT5 in MCs and the level of MIF in the medium. In conclusion, these findings indicate the important influence of signaling cascades involving MIF and STAT5 on the recruitment of MCs to gliomas. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Keywords
Mast cell; Glioma; MIF; pSTAT5
Published in
Molecular Oncology
2014, Volume: 8, number: 1, pages: 50-58
Publisher: ELSEVIER SCI LTD
Pejler, Gunnar
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
SLU Authors
UKÄ Subject classification
Immunology in the medical area
Neurosciences
Publication identifier
DOI: https://doi.org/10.1016/j.molonc.2013.09.002
Permanent link to this page (URI)
https://res.slu.se/id/publ/52766