Sammanfattning

Further, both glioma-conditioned media and purified MIF promoted differential phosphorylation of a number of signaling molecules, including signal transducer and activator of transcription 5 (STAT5), in MCs. Inhibition of pSTAT5 signaling significantly attenuated the migration of MCs toward glioma cell-conditioned medium shown to contain MIF. In addition, analysis of tissue microarrays (TMAs) of high-grade gliomas revealed a direct correlation between the level of pSTAT5 in MCs and the level of MIF in the medium. In conclusion, these findings indicate the important influence of signaling cascades involving MIF and STAT5 on the recruitment of MCs to gliomas. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Nyckelord

Mast cell; Glioma; MIF; pSTAT5

Publicerad i

Molecular Oncology
2014, Volym: 8, nummer: 1, sidor: 50-58
Utgivare: ELSEVIER SCI LTD

SLU författare

• Lundequist, Anders

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

• Pejler, Gunnar

  • Institutionen för husdjurens biovetenskaper, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Immunologi inom det medicinska området
Neurovetenskaper


Publikationens identifierare

DOI: https://doi.org/10.1016/j.molonc.2013.09.002

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/52766