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Forskningsartikel2011Vetenskapligt granskadÖppen tillgång

Fine mapping and replication of QTL in outbred chicken advanced intercross lines

Besnier, Francois; Wahlberg, Per; Rönnegård, Lars; Ek, Weronica; Andersson, Leif; Siegel, Paul B.; Carlborg, Örjan

Sammanfattning

Conclusions: Our results indicate that many of the QTL, which are genome-wide significant or suggestive in the analyses of large intercross populations, are true effects that can be replicated and fine-mapped using AIL. Key factors for success are the use of large populations and powerful statistical tools. Moreover, we believe that the statistical methods we have developed to efficiently study outbred AIL populations will increase the number of organisms for which in-depth complex traits can be analyzed.

Publicerad i

Genetics Selection Evolution
2011, Volym: 43
Utgivare: BIOMED CENTRAL LTD