Abstract

In this report we describe the main features of the initially determined alcohol dehydrogenase, that of horse liver, relate this to the human enzyme structures and review recent structural studies on mutants and new complexes of the enzymes. We further review the structure of a bacterial alcohol dehydrogenase to arrive at a coherent picture of medium-chain dehydrogenase/reductase alcohol dehydrogenases in general.

Keywords

Crystal structures; dimeric ADH; tetrameric ADH; zinc; NADH

Published in

Cellular and Molecular Life Sciences
2008, Volume: 65, number: 24, pages: 3907-3917
Publisher: BIRKHAUSER VERLAG AG

SLU Authors

• Eklund, Hans

  • Department of Molecular Biology, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Cell Biology


Publication identifier

DOI: https://doi.org/10.1007/s00018-008-8589-x

Permanent link to this page (URI)

https://res.slu.se/id/publ/77794