Sammanfattning

In this report we describe the main features of the initially determined alcohol dehydrogenase, that of horse liver, relate this to the human enzyme structures and review recent structural studies on mutants and new complexes of the enzymes. We further review the structure of a bacterial alcohol dehydrogenase to arrive at a coherent picture of medium-chain dehydrogenase/reductase alcohol dehydrogenases in general.

Nyckelord

Crystal structures; dimeric ADH; tetrameric ADH; zinc; NADH

Publicerad i

Cellular and Molecular Life Sciences
2008, Volym: 65, nummer: 24, sidor: 3907-3917
Utgivare: BIRKHAUSER VERLAG AG

SLU författare

• Eklund, Hans

  • Institutionen för molekylärbiologi, Sveriges lantbruksuniversitet
    

UKÄ forskningsämne

Cellbiologi


Publikationens identifierare

DOI: https://doi.org/10.1007/s00018-008-8589-x

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/77794