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Sammanfattning

1. This study examined hepatic cytochrome P450 (CYP450) response to dietary sesamin in combination with different n-6/n-3 fatty acid ratios in fish diet. Over a period of 4 months, fish were fed seven different experimental diets an n-6/n-3 FA ratio of either 0.5 or 1.0 in combination with two sesamin levels: low sesamin = 1.16 g/kg feed and high sesamin = 5.8 g/kg feed. Control diets did not contain sesamin.2. The CYP450-associated activities of ethoxyresorufin O-deethylase (EROD), 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylation (BFCOD), pentoxyresorufin O-depentylase (PROD), coumarin hydroxylase (COH), methoxyresorufin O-deethylase (MROD) and p-nitrophenol hydroxylase (PNPH) were significantly induced by dietary sesamin in a dose-related manner.3. Expressions of the genes CYP1A1, CYP1A3, CYP3A, AhR1 alpha, AhR2 beta, AhR2 delta and PXR involved in the regulation of CYP450 activities, was not the primary source of this induction.

Nyckelord

Fish; induction; xenobiotic metabolizing; enzymes

Publicerad i

Xenobiotica
2015, volym: 45, nummer: 7, sidor: 598-604
Utgivare: INFORMA HEALTHCARE

SLU författare

UKÄ forskningsämne

Molekylärbiologi
Biokemi

Publikationens identifierare

  • DOI: https://doi.org/10.3109/00498254.2015.1007111

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/68271