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Forskningsartikel2007Vetenskapligt granskad

Duplication of FGF3, FGF4, FGF19 and ORAOV1 causes hair ridge and predisposition to dermoid sinus in Ridgeback dogs

Hillbertz NHCS, Isaksson M, Karlsson EK, Hellmen E, Pielberg GR, Savolainen P, Wade CM, Von Euler H, Gustafson U, Hedhammar K, Nilsson M, Lindblad-Toh K, Andersson L, Andersson G

Sammanfattning

The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development

Publicerad i

Nature Genetics
2007, Volym: 39, nummer: 11, sidor: 1318-1320 Utgivare: NATURE PUBLISHING GROUP