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Sammanfattning

The dorsal hair ridge in Rhodesian and Thai Ridgeback dogs is caused by a dominant mutation that also predisposes to the congenital developmental disorder dermoid sinus. Here we show that the causative mutation is a 133-kb duplication involving three fibroblast growth factor (FGF) genes. FGFs play a crucial role in development, suggesting that the ridge and dermoid sinus are caused by dysregulation of one or more of the three FGF genes during development.

Publicerad i

Nature Genetics
2007, volym: 39, nummer: 11, sidor: 1318-1320
Utgivare: NATURE PUBLISHING GROUP

SLU författare

UKÄ forskningsämne

Veterinärmedicin
Husdjursvetenskap

Publikationens identifierare

  • DOI: https://doi.org/10.1038/ng.2007.4

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/16369