Carnrot, Cecilia
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Abstract
Nineteen lipophilic thymidine phosphate-mimicking compounds were designed and synthesized as potential inhibitors of thymidine monophosphate kinase of Bacillus anthracis, a Gram-positive bacterium that causes anthrax. These thymidine analogues were substituted at the 5'-postion with sulfonamide-, amide-, (thio)urea-, or triazole groups, which served as lipophilic surrogates for phosphate. Three of the tested compounds produced inhibition of B. anthracis Sterne growth and/or thymidine monophosphate activity. Additional studies will be necessary to elucidate the potential of this type of B. anthracis thymidine monophosphate inhibitors as novel antibiotics in the treatment Of anthrax.
Keywords
bacillus anthracis thymidine monophosphate kinase (BaTMPK); 5'-modified; thymidine-based BaTMPK kinase inhibitors
Published in
Nucleosides, Nucleotides and Nucleic Acids
2008, volume: 27, number: 3, pages: 244-260
Publisher: TAYLOR & FRANCIS INC
SLU Authors
Eriksson, Staffan
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Global goals (SDG)
SDG3 Good health and well-being
UKÄ Subject classification
Veterinary Science
Animal and Dairy Science
Publication identifier
- DOI: https://doi.org/10.1080/15257770701845238
Permanent link to this page (URI)
https://res.slu.se/id/publ/20801