Carnrot, Cecilia
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Research article2008Peer reviewed
Byun, Youngjoo; Vogel, Susan R.; Phipps, Andrew J.; Camrot, Cecilia; Eriksson, Staffan; Tiwari, Rohit; Tjarks, Werner
Nineteen lipophilic thymidine phosphate-mimicking compounds were designed and synthesized as potential inhibitors of thymidine monophosphate kinase of Bacillus anthracis, a Gram-positive bacterium that causes anthrax. These thymidine analogues were substituted at the 5'-postion with sulfonamide-, amide-, (thio)urea-, or triazole groups, which served as lipophilic surrogates for phosphate. Three of the tested compounds produced inhibition of B. anthracis Sterne growth and/or thymidine monophosphate activity. Additional studies will be necessary to elucidate the potential of this type of B. anthracis thymidine monophosphate inhibitors as novel antibiotics in the treatment Of anthrax.
bacillus anthracis thymidine monophosphate kinase (BaTMPK); 5'-modified; thymidine-based BaTMPK kinase inhibitors
Nucleosides, Nucleotides and Nucleic Acids
2008, Volume: 27, number: 3, pages: 244-260 Publisher: TAYLOR & FRANCIS INC
SDG3 Good health and well-being
Veterinary Science
Animal and Dairy Science
DOI: https://doi.org/10.1080/15257770701845238
https://res.slu.se/id/publ/20801