Wang, Liya
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Research article2013Peer reviewed
PHOSPHORYLATION OF NUCLEOSIDE-METALLACARBORANE AND CARBORANE CONJUGATES BY NUCLEOSIDE KINASES
Wang, Liya; Wojtczak, Blazej A.; Olejniczak, Agnieszka B.; Eriksson, Staffan; Lesnikowski, Zbigniew J.
Abstract
A library of purine and pyrimidine nucleosides modified with carborane or metallacarborane boron clusters at different locations, consisting of new molecules as well as already described compounds, was prepared. The compounds were tested as substrates for human deoxynucleoside kinases. Some conjugates, with modification attached to N3 of thymidine via a linker containing the triazole moiety, were efficiently phosphorylated by cytosolic thymidine kinase 1 and mitochondrial thymidine kinase 2. Higher phosphorylation levels were observed with thymidine kinase 1, the phosphorylation of nucleosides modified with metallacarboranes was observed for the first time.
Keywords
Carborane; metallacarborane; nucleoside conjugates; nucleoside kinase; phosphorylation
Published in
Nucleosides, Nucleotides and Nucleic Acids
2013, volume: 32, number: 10, pages: 571-588
Publisher: TAYLOR & FRANCIS INC
SLU Authors
Eriksson, Staffan
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
UKÄ Subject classification
Medicinal Chemistry
Publication identifier
- DOI: https://doi.org/10.1080/15257770.2013.838259
Permanent link to this page (URI)
https://res.slu.se/id/publ/55508