Abstract

The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of 0.5 (apparent negative cooperativity) for dT and 1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.

Keywords

Thymidine kinase 2; mathematical model

Published in

Nucleosides, Nucleotides and Nucleic Acids
2011, Volume: 30, number: 3, pages: 203-209
Publisher: TAYLOR & FRANCIS INC

SLU Authors

• Wang, Liya

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

• Eriksson, Staffan

  • Department of Animal Biosciences, Swedish University of Agricultural Sciences
    

UKÄ Subject classification

Biochemistry and Molecular Biology


Publication identifier

DOI: https://doi.org/10.1080/15257770.2011.563765

Permanent link to this page (URI)

https://res.slu.se/id/publ/57735