CYP1A1 activity in rainbow trout is inhibited by the environmental pollutant p-cresol

Abstract

Naturally- and anthropogenically-produced cresols could pose serious risks to fish health. In this study, three piscine CYP isoforms were investigated for their abilities to interact with p-cresol. Therefore, the activity of 7-ethoxyresorufin-O-deethylase (EROD), 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase (BFCOD), and p-nitrophenol hydroxylase (PNPH) were evaluated in the hepatic microsomes of juvenile rainbow trout. Results showed that EROD activity was inhibited in a competitive manner, BFCOD activity was inhibited in presence the highest tested p-cresol concentration and PNPH activity was not affected. These results indicate that p-cresol might affect the ability of fish to metabolize numerous aromatic hydrocarbons and dioxin compounds, which are present in the aquatic environment.

Keywords

CYP1A1; CYP3A-like; CYP2E1-like; Fish; p-Cresol

Published in

Environmental toxicology and pharmacology
2018, volume: 62, pages: 199-202
Publisher: ELSEVIER SCIENCE BV

SLU Authors

• Burkina, Viktoriia

  • Department of Molecular Sciences, Swedish University of Agricultural Sciences
    
  • University of South Bohemia in České Budějovice

• Zlabek, Vladimir

  • University of South Bohemia in České Budějovice

• Zamaratskaia, Galia

  • Department of Molecular Sciences, Swedish University of Agricultural Sciences
    
  • University of South Bohemia in České Budějovice

Global goals (SDG)

SDG6 Clean water and sanitation

UKÄ Subject classification

Pharmacology and Toxicology

Publication identifier

• DOI: https://doi.org/10.1016/j.etap.2018.07.013

Permanent link to this page (URI)

https://res.slu.se/id/publ/96651