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Sammanfattning

Microcystins, a potential threat to drinking water quality, are hepatotoxic but it has remained unclear if microcystins induce oxidative stress. We investigated if four microcystins could activate the Nrf2 pathway, a regulator of oxidative stress response. Nrf2 activity was significantly increased by microcystin-LR and-RR at 10 mu M, by microcystin-LY at 3 mu M, by [D-Asp3]-LR and by microcystin-LR at 1 mu M. Our results lend support to the suggestion that microcystins may induce oxidative stress response. (C) 2016 Elsevier Ltd. All rights reserved.

Nyckelord

Microcystins; Oxidative stress; Nrf2

Publicerad i

Toxicon
2017, volym: 126, sidor: 47-50

SLU författare

Globala målen (SDG)

SDG6 Rent vatten och sanitet för alla

UKÄ forskningsämne

Arbetsmedicin och miljömedicin
Farmakologi och toxikologi

Publikationens identifierare

  • DOI: https://doi.org/10.1016/j.toxicon.2016.12.012

Permanent länk till denna sida (URI)

https://res.slu.se/id/publ/88794