Wang, Liya
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
Abstract
The mitochondrial enzyme thymidine kinase 2 (TK2) phosphorylates deoxythymidine (dT) and deoxycytidine (dC) to form dTMP and dCMP, which in cells rapidly become the negative-feedback end-products dTTP and dCTP. TK2 kinetic activity exhibits Hill coefficients of 0.5 (apparent negative cooperativity) for dT and 1 for dC. We present a mathematical model of TK2 activity that is applicable if TK2 exists as two monomer forms in equilibrium.
Keywords
Thymidine kinase 2; mathematical model
Published in
Nucleosides, Nucleotides and Nucleic Acids
2011, volume: 30, number: 3, pages: 203-209
Publisher: TAYLOR & FRANCIS INC
SLU Authors
Eriksson, Staffan
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
- Department of Animal Biosciences, Swedish University of Agricultural Sciences
UKÄ Subject classification
Biochemistry
Molecular Biology
Publication identifier
- DOI: https://doi.org/10.1080/15257770.2011.563765
Permanent link to this page (URI)
https://res.slu.se/id/publ/57735